'Weakened version of the virus': scientists have figured out how a person affects the SARS-CoV-2 mutation - ForumDaily
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'Weakened version of the virus': scientists have found out how a person affects the SARS-CoV-2 mutation

Researchers say SARS-CoV-2 undergoes mutation due to human proteins that degrade it. But, despite this, the system of “natural selection” inherent in the virus allows it to recover, writes Fox News.

Photo: Shutterstock

Scientists from the University of Bath in the UK and the University of Edinburgh say their research could help develop vaccines to fight the virus. In a statement, the researchers note that all organisms mutate, but this is usually a random process as a result of mistakes made when copying DNA.

“In the case of SARS-CoV-2, mutation may not be a random process, and instead people promote its mutation as part of a defense mechanism for the degradation of the virus,” they explain.

The research is published in the journal Molecular Biology and Evolution.

After studying more than 15 viral genomes in research projects around the world, scientists have identified 000 mutations.

“We studied how much each of the four components of the virus's genetic code (denoted by the letters A, C, U and G) mutates, and found that the virus has a very high mutation rate in the U component,” the scientists said.

They explained that this is a kind of “fingerprint” of the mutational profile of APOBEC, a human protein that can cause viruses to mutate.

“Natural selection (survival of the fittest) allows the virus to fight the mutation process,” the researchers noted.

On the subject: Nine times infectious: a new strain of coronavirus is spreading in the US and Europe

"I've looked at the mutational profiles of many organisms and they all show some kind of effect, but I've never seen something as strong and strange as this before," explained lead author Professor Lawrence Hirst, director of the Milner Center for Evolution at the University of Bath.

The results may have implications for vaccine development.

“This knowledge will allow us to understand what a weakened version of the virus should look like,” Hurst said. “We suggest that increasing the U component, as APOBEC does in our cells, would be a reasonable strategy.”

As of Friday morning, July 24, more than 15,5 million cases of coronavirus have been diagnosed worldwide, with more than 4 million of them in the United States. The disease has killed more than 634 people worldwide, including more than 000 in the United States.

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